![]() ![]() The trial in people aged 16 years and older also showed around 95% efficacy in the participants at risk of severe COVID-19, including those with asthma, chronic lung disease, diabetes, high blood pressure or obesity. This means that the vaccine demonstrated a 95% efficacy in the trial. The study showed a 95% reduction in the number of symptomatic COVID-19 cases in the people who received the vaccine (8 cases out of 18,198 got COVID-19 symptoms) compared with people who received a dummy injection (162 cases out of 18,325 got COVID-19 symptoms). People did not know whether they received the vaccine or the dummy injection.Įfficacy in people aged 16 and above was calculated in over 36,000 participants (including people over 75 years of age) who had no sign of previous infection. Half received the vaccine and half were given a dummy injection. The trial involved around 44,000 people aged 16 and above in total. What benefits of Comirnaty have been shown in studies?Ī very large clinical trial showed that Comirnaty, given as a two-dose regimen, was effective at preventing COVID-19 in people from 12 years of age. The mRNA from the vaccine is broken down after vaccination and removed from the body. If, later on, the person comes into contact with SARS-CoV-2, their immune system will recognise it and be ready to defend the body against it. ![]() The person’s immune system will then recognise the protein as foreign and produce antibodies and activate T cells (white blood cells) to attack it. When a person is given the vaccine, some of their cells will read the mRNA instructions and temporarily produce the spike protein. Adapted vaccines work in the same way as Comirnaty and are expected to broaden protection against the virus as they also contain mRNA matching other variants of the virus. This is a protein on the surface of the SARS-CoV-2 virus which the virus needs to enter the body’s cells, and can differ between variants of the virus. It contains a molecule called mRNA which has instructions for making the spike protein. The vaccines should be used according to official recommendations issued at national level by public health bodies.įor more information about using Comirnaty or its adapted vaccines, see the package leaflet or consult a healthcare professional.Ĭomirnaty works by preparing the body to defend itself against COVID-19. The injections can be given in the muscles of the upper arm or thigh.Ī booster dose of Comirnaty 30 micrograms per dose may be given to people aged 12 years and older at least 3 months after primary vaccination with a COVID-19 vaccine.Ī booster dose of Comirnaty 10 micrograms per dose may be given to children from 5 to 11 years of age at least 6 months after the primary vaccination course.Ī booster dose of Comirnaty Original/Omicron BA.1 or Comirnaty Original/Omicron BA.4-5 (30 micrograms per dose) may be given to people aged 12 years and older at least 3 months after primary vaccination or a booster dose with a COVID-19 vaccine.Ī booster dose of Comirnaty Original/Omicron BA.4-5 (10 micrograms per dose) may be given to people aged from 5 years to 11 years after primary vaccination or a booster dose with a COVID-19 vaccine. In children from 6 months to 4 years of age, Comirnaty is given as three doses of 3 micrograms each the first two doses are given three weeks apart, followed by a third dose given at least 8 weeks after the second dose. Adults and adolescents from the age of 12 are given 30 micrograms per dose children aged 5 to 11 years are given 10 micrograms per dose.Īn additional dose of Comirnaty may be given to people aged 5 years and older with a severely weakened immune system, at least 28 days after their second dose. For really young children, between 6 months and 3 years old, you’ll often see soreness at the injection site, but also swollen lymph nodes, irritability, sleepiness or loss of appetite.In adults and children from 5 years of age, Comirnaty is given as two injections, usually into the muscle of the upper arm, 3 weeks apart. In kids, the most common side effects are a bit different. Other common side effects of the COVID-19 vaccine in adults - whether it’s the updated formula or not - include headaches, fever, chills and nausea, according to the Centers for Disease Control and Prevention. “Most often it’s redness at the site of inoculation, some soreness, feeling tired for a day or two afterwards - all the same side effects we’re seeing at relatively the same rates with the bivalent booster.” “All the side effects from the bivalent booster (in clinical trials) were very similar to what we saw with the regular booster and even going back to the initial vaccination,” said Andrew Pekosz, a virologist with the Johns Hopkins Bloomberg School of Public Health, in a recent media briefing. ![]() Older adults at higher risk for Alzheimer’s after having COVID: Study ![]()
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